
ET
Sep 7, 2003, 11:36 AM
Post #8 of 8
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Re: [TomG] One Downside - Travel in Mexico
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TomG writes: ....I recently had a rather severe skin outbreak and an increase in tinnitus thought to be a reaction to Choroquine.... Chloroquine-related ototoxicity is considered to be rare. It is mostly associated with users who have pre-existing auditory damage, which serves to emphasize why advice regarding medications should be obtained from a health care professional familiar with your health profile and what other medications you're using. Both skin rashes and itching are considered to be not-uncommon side effects of chloroquine, to the point that medical attention is only recommended if the condition persists and/or bothersome.
TomG writes: ....My uncle who has lived in New Guinea for 30+ years has severe ear trouble and some eye trouble attributed to it. Many of his associates suffer from it effects, and now none use it. The medical advice given them is to instead deal with the mosquitoes or malaria directly..... When chloroquine is prescribed at dose rates in excess of those typically used for prophylactic treatments, or when prescribed for long term use (calculated using a simple cumulative dose formula), periodic monitoring (typically every 3-6 months, but again dependent on a health care professional's assessment of the individual) is recommended including complete blood counts, a neuromuscular exam, and full ophthalmologic exam. Abnormalities and impacts found at the early stages by such monitoring are expected to be reversible. Additionally I'm not sure why relatives and friends in New Guinea were using chloroquine in the first place. Unlike Mexico, chloroquine-resistant malaria is present, with resistant Plasmodium falciparum being first identified in the mid-70's, and resistant Plasmodium vivax in the late 80's. The "sliding your chips onto the table" type of drama is unnecessary. If you are going to be spending your time in areas where there's a risk of malaria and your activities and/or lifestyle places you at significant risk of exposure, there are several alternate prophylactic treatments which can be used in cases of chloroquine sensitivity. A health care professional familiar with travel medicine or "tropical" and/or parasitic diseases and their prevention should be familiar with them.
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