It's fine to cross at Anzalduas bridge at Mission and then get on the Autopista ( Hwy 40) to Monterrey. What you want to avoid is the route that takes you south through central/southern Tamaulipas (San Fernando/Ciudad Victoria). I wouldn't drive on Highway 2 between Progreso and Reynosa because there isn't any utility in doing that if you are going from eastern Hidalgo County to Monterrey on the Autopista. Highway 83 on the Texas side is in much better condition, a much quicker route and doesn't have the issues the river road has on the other side.
(This post was edited by Altahabana on Jun 11, 2012, 6:55 PM)
Post edited by Altahabana
(Enthusiast) on Jun 11, 2012, 6:55 PM